梁丹,发育生物学博士,教授,博士生导师,安徽医科大学东南人才三类,合肥C类高层次人才。
课题组长期致力小鼠与人的早期胚胎发育、体细胞重编程与生殖医学领域相关研究,在Cell Stem Cell ,Nature Communications 以及 Protein Cell等国际重要期刊上发表多篇学术论文。
邮箱:ahmuxl@sina.com
教育与研究经历:
2020.09-至今 安徽医科大学校聘教授,国家卫生健康委配子及生殖道异常研究重点实验室PI
2017.02-2020.08 美国俄勒冈健康与科技大学胚胎干细胞与基因治疗中心Shoukhrat Mitalipov 研究组,博士后
2010.09-2016.07 中国科学院上海生物化学与细胞生物所李劲松院士课题组,发育生物学博士
科研项目:
1. 国家重点研发计划子课题一骨干,2023-12至2028-11,154万,在研;
2. 主持国家自然基金青年项目,2022-1至2024-12, 30万,在研;
3. 国家重点研发计划子课题一骨干, 2021-12至2024-11,28.5万, 在研;
4. 主持安徽省高校自然研究重点项目, 2021-01-至2022-12,6万,已结题;
5.国家自然科学基金重点项目, 2016-01至2020-12,330.4万元,已结题,主要参与人.
6.国家自然科学基金重大研究计划, 2014-01至2016-12,300万元,已结题,主要参与人。
已发表工作:
1. Liang, D., Mikhalchenko, A., Ma, H., Marti Gutierrez, N., Chen, T., Lee, Y., Park, S.W., Tippner-Hedges, R., Koski, A., Darby, H., et al. (2023). Limitations of gene editing assessments in human preimplantation embryos. Nature Communications 14, 1219. 10.1038/s41467-023-36820-6.
2. Yang, F., Xu, S., Huang, C., Shao, Z., Hu, Y., Yang, Y., Lai, Y., Ke, Q., Liang, D. #, and Wu, Y#. (2023). Therapeutic genome editing of an aberrant splice site in β-thalassemia by CRISPR/Cas9 with multiple sgRNAs. Genes & Diseases. 10.1016/j.gendis.2023.01.010. (# 共同通讯)
3. Yang, F., Wang, Y., Wang, Q., Pang, J., Liu, G., Yang, Y., Qin, S., Zhang, Y., Lai, Y., Fu, B., Zhu, Y., Wang, M., Kurita, R., Nakamura, Y., Liang, D. #, and Wu, Y#. (2023). Efficient repair of human genetic defect by CRISPR/Cas9-mediated interlocus gene conversion. Life Medicine 2. 10.1093/lifemedi/lnad042. (# 共同通讯)
4. Bai,M*, Liang, D.*, Cheng, Y.*, Li,J. and Wu, Y. (2022). Gonadal mosaicism mediated female-biased gender control in mice. Protein Cell. 10.1007/s13238-022-00910-w. (* 共同一作)
5. Xing, F., Wang, M., Ding, Z., Zhang, J., Ding, S., Shi, L., Xie, Q., Ahmad, M.J., Wei, Z., Tang, L., Liang, D. #, Cao, Y #, and Liu, Y.J#. (2022). Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice. J Clin Med 11. 10.3390/jcm11247383. (# 共同通讯)
6. Ji, D., Su, X., Hu, C., Zhang, Z., Wang, M., Zou, W., Shen, L., Liu, Y., Liang, C., Du, Y. #, Liang, D. #, Cao, Y #. (2022). Generation of an induced pluripotent stem cell line from a patient with leber's hereditary optic neuropathy carrying a homoplasmic m.3635G > A mutation in the mitochondrial ND1 gene. Stem Cell Res 63, 102858. 10.1016/j.scr.2022.102858. (# 共同通讯)
7. Xie, F., Zhang, J., Zhai, M., Liu, Y., Hu, H., Yu, Z., Zhang, J., Lin, S., Liang, D. #, and Cao, Y#. (2021). Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway. Reproduction 162, 73-82. 10.1530/REP-20-0643. (# 共同通讯)
8. Xie, Q.E., Wang, M.Y., Cao, Z.P., Du, X., Ji, D.M., Liang, D. #, Cao, Y.X. #, and Liu, Y.J#. (2021). Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells. Mitochondrion 61, 44-53. 10.1016/j.mito.2021.09.009. (# 共同通讯)
9. Bai, M.*, Liang, D.*, Wang, Y., Li, Q., Wu, Y., and Li, J. (2016). Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9. Journal of Genetics and Genomics 43, 289-296. (* 共同一作)
10. Guo, F. *, Li, X. *, Liang, D. *, Li, T. *, Zhu, P., Guo, H., Wu, X., Wen, L., Gu, T.P., Hu, B., et al. (2014). Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote. Cell stem cell 15, 447-458. (* 共同一作)
11.Wu, Y*, Liang, D.*, Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., and Li, J. (2013). Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell 13, 659-662.(* 共同一作)