梁丹，发育生物学博士，教授，博士后导师，安徽医科大学 “东南学者”，安徽省高层次人才，安徽省高校优秀青年科学基金获得者及安徽省青年拔尖人才。课题组长期聚焦于早期胚胎发育及基因组稳态维持相关研究方向，在Nature Cell Biology、Cell Stem Cell、Nature Communications、Protein & Cell等国际重要期刊上发表多篇学术论文。
邮箱：ahmuxl@sina.com
教育与研究经历：
2020.09-至今 安徽医科大学校聘教授，国家卫生健康委配子及生殖道异常研究重点实验室PI
2017.02-2020.08 美国俄勒冈健康与科技大学胚胎干细胞与基因治疗中心Shoukhrat Mitalipov 研究组，博士后
2010.09-2016.07 中国科学院上海生物化学与细胞生物所李劲松院士课题组，发育生物学博士
科研项目：
1. 主持安徽省高校优青科研项目，2025-01至2027-12，50万，在研；
2. 主持安徽省转化医学研究院重点项目， 2024-01至2026-11，20万，在研；
3. 国家重点研发计划子课题一骨干，2023-12至2028-11，154万，在研；
4. 主持国家自然基金青年项目，2022-1至2024-12, 30万，已结题；
5. 国家重点研发计划子课题一骨干， 2021-12至2024-11，28.5万, 已结题；
6. 主持安徽省高校自然研究重点项目， 2021-01-至2022-12，6万，已结题；
7. 国家自然科学基金重点项目， 2016-01至2020-12，330.4万，已结题，主要参与人；
8. 国家自然科学基金重大研究计划， 2014-01至2016-12，300万，已结题，主要参与人。
已发表工作：
1. Xu, S.*, Liang, D.*, Cheng, Y.*, Sun, G.*, Zhao, F., Yang, Y., Zhang, H., Lai, Y., Fu, B., & Wu, Y. (2025). Lentiviral vectors for gene therapy of α-thalassemia. Science China. Life sciences. 10.1007/s11427-024-2820-9. (* 共同一作)
2. Geng, H.*, Wang, K.*, Liang, D.*, Ni, X.*, Yu, H., Tang, D., Lv, M., Wu, H., Li, K., Shen, Q., Gao, Y., Xu, C., Zhou, P., Wei, Z., Cao, Y., Sha, Y., Yang, X., & He, X. (2024). Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variants. iScience. 10.1016/j.isci.2024.110366(* 共同一作)
3. Liang, D.* #, Yan, R., Long, X., Ji, D., Song, B., Wang, M., Zhang, F., Cheng, X., Sun, F., Zhu, R., Hou, X., Wang, T., Zou, W., Zhang, Y., Pu, Z., Zhang, J., Zhang, Z., Liu, Y., Hu, Y., He, X., Cao, Y. #, Guo, F #. (2024). Distinct dynamics of parental 5-hydroxymethylcytosine during human preimplantation development regulate early lineage gene expression. Nature cell biology. 10.1038/s41556-024-01475-y. (#共同通讯，* 共同一作)
4. Ding, S. M., Shi, L. G., Cao, Z. P., Zhu, N. N., Liu, Y. Y., Wang, M. Y., Cui, S. S., Cheng, H. R., Liang, D. #, Cao, Y. X. #, & Liu, Y. J#. (2024). HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest. Heliyon. 10.1016/j.heliyon.2024.e33132.(#共同通讯)
5. Liang, D. *, Mikhalchenko, A. *, Ma, H., Marti Gutierrez, N., Chen, T., Lee, Y., Park, S.W., Tippner-Hedges, R., Koski, A., Darby, H., et al. (2023). Limitations of gene editing assessments in human preimplantation embryos. Nature Communications. 10.1038/s41467-023-36820-6. （* 共同一作）
6. Yang, F., Xu, S., Huang, C., Shao, Z., Hu, Y., Yang, Y., Lai, Y., Ke, Q., Liang, D. #, and Wu, Y#. (2023). Therapeutic genome editing of an aberrant splice site in β-thalassemia by CRISPR/Cas9 with multiple sgRNAs. Genes & Diseases. 10.1016/j.gendis.2023.01.010. (#共同通讯)
7. Yang, F., Wang, Y., Wang, Q., Pang, J., Liu, G., Yang, Y., Qin, S., Zhang, Y., Lai, Y., Fu, B., Zhu, Y., Wang, M., Kurita, R., Nakamura, Y., Liang, D.#, and Wu, Y #. (2023). Efficient repair of human genetic defect by CRISPR/Cas9-mediated interlocus gene conversion. Life Medicine. 10.1093/lifemedi/lnad042. (#共同通讯)
8. Bai,M*, Liang, D.*, Cheng, Y.*, Li,J. and Wu, Y. (2022). Gonadal mosaicism mediated female-biased gender control in mice. Protein Cell. 10.1007/s13238-022-00910-w.(* 共同一作)
9. Xing, F., Wang, M., Ding, Z., Zhang, J., Ding, S., Shi, L., Xie, Q., Ahmad, M.J., Wei, Z., Tang, L., Liang, D. #, Cao, Y #, and Liu, Y.J#. (2022). Protective Effect and Mechanism of Melatonin on Cisplatin-Induced Ovarian Damage in Mice. J Clin Med. 10.3390/jcm11247383. (#共同通讯)
10. Ji, D., Su, X., Hu, C., Zhang, Z., Wang, M., Zou, W., Shen, L., Liu, Y., Liang, C., Du, Y. #, Liang, D. #, Cao, Y #. (2022). Generation of an induced pluripotent stem cell line from a patient with leber's hereditary optic neuropathy carrying a homoplasmic m.3635G > A mutation in the mitochondrial ND1 gene. Stem Cell Res. 10.1016/j.scr.2022.102858. (# 共同通讯)
11. Xie, F., Zhang, J., Zhai, M., Liu, Y., Hu, H., Yu, Z., Zhang, J., Lin, S., Liang, D. #, and Cao, Y#. (2021). Melatonin ameliorates ovarian dysfunction by regulating autophagy in PCOS via the PI3K-Akt pathway. Reproduction. 10.1530/REP-20-0643. (#共同通讯)
12. Xie, Q.E., Wang, M.Y., Cao, Z.P., Du, X., Ji, D.M., Liang, D. #, Cao, Y.X. #, and Liu, Y.J#. (2021). Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells. Mitochondrion. 10.1016/j.mito.2021.09.009. (#共同通讯)
13. Bai, M.*, Liang, D.*, Wang, Y., Li, Q., Wu, Y., and Li, J. (2016). Spermatogenic Cell-Specific Gene Mutation in Mice via CRISPR-Cas9. Journal of Genetics and Genomics. 10.1016/j.jgg.2016.02.003 （* 共同一作）
14. Guo, F. *, Li, X. *, Liang, D. *, Li, T. *, Zhu, P., Guo, H., Wu, X., Wen, L., Gu, T.P., Hu, B., et al. (2014). Active and passive demethylation of male and female pronuclear DNA in the Mammalian zygote. Cell stem cell. 10.1016/j.stem.2014.08.003 （* 共同一作）
15. Wu, Y*, Liang, D.*, Wang, Y., Bai, M., Tang, W., Bao, S., Yan, Z., Li, D., and Li, J. (2013). Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell. 10.1016/j.stem.2013.10.016（* 共同一作）
