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蒋祥祥

发布时间:2020-08-15 浏览次数:12

主要研究哺乳动物(人、食蟹猴、小鼠等)母胎界面细胞发育和功能,即以胎盘为中心,利用干湿结合(生物信息分析和其他细胞与分子生物学实验技术)方法研究胎盘和胚胎细胞发育及母体蜕膜免疫细胞功能。以第一作者和通讯作者(含共同)在Science、Nature、Developmental Cell、Cellular & Molecular Immunology、Cell Discovery等期刊发表SCI论文12篇。主持多项国家自然科学基金和国家重点研发计划子课题(含骨干),并获得第五届全国妇幼健康科学技术奖一等奖。

 

邮箱:jiangxx@ahmu.edu.cn

 

教育和研究经历:

2021.05-至今       安徽医科大学,国家卫生健康委配子及生殖道异常研究重点实验室,校聘教授,博士生导师,独立PI

2018.07-2021.04 中国科学院动物研究所,博士后兼特别研究助理

2012.09-2018.06 中国科学院动物研究所,干细胞与生殖生物学国家重点实验室,理学博士,再生医学专业

2008.09-2012.06 安徽医科大学,生命科学学院,理学学士,生物技术专业

 

代表论文:  (#, equal contribution; *, corresponding authors)

1. Jiang Xiangxiang#, Zhai Jinglei#, Xiao Zhenyu#, Wu Xulun#, Zhang Dan#, Wan Haifeng, Xu Yanhong, Qi Luqing, Wang Meijiao, Yu Dainan, Liu Yawei, Wu Hao, Sun Run, Xia Shuwei, Yu Kunyuan, Guo Jingtao, Wang Hongmei*. Identifying a dynamic transcriptomic landscape of the cynomolgus macaque placenta during pregnancy at single-cell resolution. Developmental Cell. 2023;58(9):806-21.e7.

2. Zhai Jinglei#, Guo Jing#, Wan Haifeng#, Qi Luqing#, Liu Lizhong#, Xiao Zhenyu, Yan Long, Schmitz Daniel A., Xu Yanhong, Yu Dainan, Wu Xulun, Zhao Wentao, Yu Kunyuan, Jiang Xiangxiang*, Guo Fan*, Wu Jun*, Wang Hongmei*. Primate gastrulation and early organogenesis at single-cell resolution. Nature. 2022;612(7941):732-8.

3. Ma Huaixiao#, Zhai Jinglei#, Wan Haifeng#, Jiang Xiangxiang#, Wang Xiaoxiao, Wang Lin, Xiang Yunlong, He Xiechao, Zhao Zhen-Ao, Zhao Bo, Zheng Ping*, Li Lei*, Wang Hongmei*. In vitro culture of cynomolgus monkey embryos beyond early gastrulation. Science. 2019;366(6467):eaax7890.

4. Jiang Xiangxiang#*, Wang Yue#, Xiao Zhenyu, Yan Long, Guo Shanshan, Wang Yiming, Wu Hao, Zhao Xuehan, Lu Xiaoyin*, Wang Hongmei*. A differentiation roadmap of murine placentation at single-cell resolution. Cell Discovery. 2023;9(1):30.

5. Jiang Xiangxiang#, Du Mei-Rong, Li Min, Wang Hongmei*. Three macrophage subsets are identified in the uterus during early human pregnancy. Cellular & Molecular Immunology. 2018;15(12):1027-37.

6. Jiang Xiangxiang#*, Wang Hongmei*. Macrophage subsets at the maternal-fetal interface. Cellular & Molecular Immunology. 2020;17(8):889-91.

7. Zhou Jingjing#, Jiang Xiangxiang#, Wu Haowei#, Zhang Lianjun, Chen Min, Chen Min, Shen Zhiming, Guo Xudong*, Wang Hongmei*, Gao Fei*. Dissecting the fate of Foxl2-expressing cells in fetal ovary using lineage tracing and single-cell transcriptomics. Cell Discovery. 2022;8(1):139.

8. Liang Guixian#, Zhou Chunyu#, Jiang Xiangxiang#, Zhang Yifan, Huang Baofeng, Gao Suwei, Kang Zhixin, Ma Dongyuan, Wang Fengchao, Gottgens Berthold*, Wang Hongmei*, Han Jing-Dong J.*, Liu Feng*. De novo generation of macrophage from placenta-derived hemogenic endothelium. Developmental Cell. 2021;56(14):2121-33.e6.

9. Wang Yiming#, Jiang Xiangxiang#, Jia Lei#, Wu Xulun#, Wu Hao#, Wang Yue, Li Qian, Yu Ruoxuan, Wang Hongmei*, Xiao Zhenyu*, Liang Xiaoyan*. A Single-Cell Characterization of Human Post-implantation Embryos Cultured In Vitro Delineates Morphogenesis in Primary Syncytialization. Frontiers in Cell and Developmental Biology. 2022;10.

10. Cui Dong# , Liu Yawei# , Jiang Xiangxiang#, Ding Chuling , Poon Liona C. *, Wang Hongmei* , Yang Huixia*. Single-cell RNA expression profiling of SARS-CoV-2-related ACE2 and TMPRSS2 in human trophectoderm and placenta. Ultrasound in Obstetrics and Gynecology. 2021;57(2):248-56.

 

科研项目:

国家重点研发计划,课题负责人2023-2028)

国家重点研发计划,骨干(2020-2024

安徽省自然科学基金优青项目,主持(2023-2026)

国家自然科学基金面上项目,主持(2024-2027)

国家自然科学基金青年基金,主持(2020-2022

安徽医科大学引进人才博士科研启动经费,主持(2021-2026

安徽医科大学科研水平提升计划,主持(2022-2024

 

获奖情况:

第五届全国妇幼健康科学技术奖自然科学一等奖(2023-Z-F-7-05

相关科研成果报道:
https://kjc.ahmu.edu.cn/2023/0414/c9364a135551/page.htm

https://mp.weixin.qq.com/s/QRFtgZjeQ_odeIZQ5Jry3Q

https://xcb.ahmu.edu.cn/2023/0131/c4933a132242/page.htm

https://mp.weixin.qq.com/s/-MQXWjIFJ0vJ-BIK6bBMUA

http://szyc.ayfy.com/page95?article_id=292

https://mp.weixin.qq.com/s/tC1BckN_y1WJ1OWChD03rA

https://mp.weixin.qq.com/s/f8qIpBOKXOYgCrDZJmu4fw

https://mp.weixin.qq.com/s/7e87PUwYLhs2jSBT9DQOXg